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Investigation of the integrity of the ryanodine receptor in Alzheimer's disease is important because it plays a critical role in the regulation of calcium release from the endoplasmic reticulum in brain, impairment of which is believed to contribute to the pathogenesis of Alzheimer's disease. The present study compared ryanodine receptor levels and their functional modulation in particulate fractions...
Inositol 1,4,5-trisphosphate (IP 3 ), inositol 1,3,4,5-tetrakisphosphate (IP 4 ) and protein kinase C (PKC) play important roles in the phosphoinositide hydrolysis signal transducing pathway. Several studies have shown severe deficits in both IP 3 receptor levels and PKC levels and activity in Alzheimer's disease brain, although the relationship of these changes to disease...
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