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The Phospho-Ser 262 epitope of phosphorylated tau, which accumulates in tangles in Alzheimer's disease (AD) brains, has been shown to have a strong disruptive effect on microtubules. Using antibodies which specifically recognize the Phospho-Ser 262 of tau, we compared the presence of this epitope in normal appearing neurons (pre-tangles) and tangles, with the presence...
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