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Mossy fiber sprouting (MFS), a common feature of human temporal lobe epilepsy and many epilepsy animal models, contributes to hippocampal hyperexcitability. The molecular events responsible for MFS are not well understood, although the growth-associated protein GAP-43 has been implicated in rats. Here, we focus on the hyaluronan receptor CD44, which is involved in routing of retinal axons during development...
We have previously shown that β-amyloid (Aβ) increased the excitotoxicity of ibotenate, an N-methyl-d-aspartate (NMDA) receptor agonist, to hippocampal neurons of rats. In this report, non-toxic amounts of kainate were co-injected with Aβ into rat hippocampus. Nissl-stained brain sections revealed that Aβ/kainate co-injection exerted synergistic neuronal degeneration in the hippocampus as well as...
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