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Hypoxia inducible factor (HIF) controls the transcription of genes involved in angiogenesis, erythropoiesis, glycolysis, and cell survival. HIF-1α levels are a critical determinant of HIF activity. The induction of HIF-1α was examined in the livers of mice treated with a toxic dose of APAP (300mg/kg IP) and sacrificed at 1, 2, 4, 8, and 12h. HIF-1α was induced at 1–12h and induction occurred prior...
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