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L'influence du stress sur l'immunité et la pathogenèse met en cause l'axe corticotrope : hypothalamus–hypophyse–surrénales (HHS). Sa surstimulation du fait de traumatismes pendant la prime enfance ou la vie fœtale serait génératrice d'anomalies cérébrales comme la diminution du volume de l'hippocampe. Plus caractéristique de l'âge adulte, l'axe hypothalamus–glande pinéale (HP), responsable de la sécrétion...
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