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5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene (LT) A 4 and 5-hydroperoxyeicosatetraenoic acid. LTA 4 can then be converted into LTB 4 by LTA 4 hydrolase or into LTC 4 by LTC 4 synthase and the LTC 4 synthase isoenzymes MGST2 and MGST3. LTB 4 is a potent chemoattractant for neutrophils, eosinophils...
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