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Adenosine A 2A receptor antagonists alleviate memory deficits caused by aging or by administration of β-amyloid peptides in rodents, which is in accordance with the beneficial effects of caffeine consumption (an adenosine receptor antagonist) on memory performance in aged individuals and in preventing Alzheimer's disease. We now tested if A 2A receptor blockade affords a general beneficial...
Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured neurons against β-amyloid-induced toxicity, an effect mimicked by adenosine A 2A but not A 1 receptor antagonists. We now tested if caffeine administration would prevent β-amyloid-induced cognitive impairment...
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