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Aging-related differences in the ability of cortical cholinergic inputs to respond to local depolarization was assessed in young (3-6 months) and old (26-33 months) awake rats using in vivo microdialysis in the absence of an inhibitor of acetylcholinesterase. Rats were perfused, using a within-subjects, repeated session design, with vehicle (aCSF) or K + (25, 50, 100mM). Perfusion of K ...
Using in vivo microdialysis, cortical acetylcholine (ACh) efflux was measured in freely moving Brown Norway/Fischer 344 F1 rats, aged 4 or 22 months. The effects of local, intracortical perfusion of atropine (1.0 or 100.0 μM) via the dialysis probe were compared to local K + (100.0 mM) stimulation in the presence of elevated extracellular Ca 2+ (2.5 mM). Basal cortical ACh efflux...
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