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Twenty six 18β-glycyrrhetinic acid (GA) (1) derivatives 2–27 including twelve new GA derivatives 10, 11, 13–17, 21–25 were synthesized and evaluated for cytotoxicities against NTUB1 cells (human bladder cancer cell lines). seco-Compounds 9, 25, and 27 are the most potent compounds of this series, inhibiting cell growth of human NTUB1 cells with an IC 50 values of 2.34±0.28, 4.76±1.15, and...
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