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ADAMs are membrane anchored glycoproteins that contain a disintegrin and metalloprotease domain. This chapter will focus on recent insights that have emerged from studies of “knockout” mice for ADAM proteases that are widely expressed or at least expressed in a variety of different cells and tissues (ADAMs 8, 9, 10, 12, 15, 17 and 19). These studies have shown that ADAM10 is important for signaling...
Molecular targeted therapies for head and neck cancer offer promising opportunities to improve upon clinical outcomes of conventional treatments. The toxicity profiles of these agents are unique, reflecting their distinct mechanisms of action, and generally do not appear to directly overlap or amplify the toxicities of conventional treatment modalities. Herein, we discuss strategies for targeting...
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