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The Mitogen-Activated Protein Kinase Kinase 4 (MKK4, also referred to as JNKK1, SEK2, or MEK4) has been identified as a metastasis suppressor gene in prostate and ovarian cancer. Metastasis suppressor genes are defined by the ability of their encoded proteins to suppress the development of metastases in vivo without affecting primary tumor growth when transfected into metastatic cell lines. Studies...
Metastasis of cancer cells from the primary tumor to form macroscopic lesions at the secondary site is the primary cause of morbidity and mortality in cancer patients. Thus, an understanding of the mechanisms controlling metastasis would allow more effective treatments resulting in better quality of life and higher survival rates. Metastasis suppressor genes prevent metastasis without affecting tumorigenesis...
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