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Maspin is a novel serine protease inhibitor differentially expressed in several types of human cancers. Accumulated evidence indicates that maspin plays a tumor suppressive role at the steps of tumor growth, invasion, tumor-induced extracellular matrix remodeling and angiogenesis, and tumor metastasis. Several recent studies also suggest that maspin plays a role in restoring a more differentiated...
Serum PSA, Gleason score, pathological stage, and positive surgical margins are currently used as predictors for disease recurrence. However, these criteria are less than precise in predicting disease outcome, with only 10% specificity at the 90% sensitivity level. Keratins are intermediate filament proteins that are contained within normal epithelia. However, human prostate cancer tissue shows differential...
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