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Functional polymorphisms of tumor necrosis factor‐alpha (TNF‐α) may play a critical role in the regulation of immune and inflammatory responses and could affect transcriptional levels of the TNF‐α gene and thus contribute to carcinogenesis and outcomes of cancer patients. In a cohort study, we explored the associations between TNF‐α polymorphisms and risk of recurrence of squamous cell carcinoma of...
The promoter variants of TNF‐α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF‐α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated associations of four TNF‐α polymorphisms with risk of recurrence in a cohort of 846 patients...
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