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Aims/hypothesis. Rosiglitazone is used to treat Type 2 diabetes because it improves insulin sensitivity. However, the specific molecular mechanism by which this compound acts has not yet been explained. Methods. We used fetal rat primary brown adipocytes cultured for 24h with or without 10mol/l rosiglitazone and further stimulated for 5min with 10nmol/l insulin. Next we measured glucose uptake and...
Aims/hypothesis. We examined the properties of a mutant insulin receptor (IR) with an Arg252 to Cys (IRR252C) substitution in the -subunit originally identified in a patient with extreme insulin resistance and acanthosis nigricans. Methods. We studied IR cell biology and signalling pathways in Chinese Hamster Ovary cells overexpressing this IRR252C. Results. Our investigation showed an impairment...
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