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A variety of mutations in the p53 tumor suppressor gene have been found in over half of human tumors. Thus, restoration of wild-type p53 activity by repair of mutant RNA has been previously suggested as an approach to cancer treatment. To explore the potential utility of RNA repair for cancer therapy, we developed a group I intron-based ribozyme that can replace mutant p53 RNA with a wild-type RNA...
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinomaClayman G.L. et al. (1998)J. Clin. Oncol. 16, 2221-2232Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacementRoth, J.A. et al. (1998)Semin. Oncol. 25, 33-37
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