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Objective
To investigate changes in depressive and suicidality status and their relationship with seizure outcomes after the addition or substitution of another antiseizure medication (ASM) in adults with drug‐resistant focal epilepsy.
Methods
Seven hundred seventy consecutively enrolled patients were assessed and followed prospectively for seizure outcome and depressive status over a 6‐month period...
Objective
To re‐assess the definition of drug‐resistant epilepsy based on the evidence from a large‐scale, long‐term study including both adults and children. We categorized the patients as idiopathic generalized epilepsies (IGEs), focal epilepsies, or structural‐metabolic‐genetic generalized epilepsies [symptomatic generalized epilepsies (SGEs)] and provided the definition of drug‐resistance based...
Objective
Although many studies have attempted to describe treatment outcomes in patients with drug‐resistant epilepsy, results are often limited by the adoption of nonhomogeneous criteria and different definitions of seizure freedom. We sought to evaluate treatment outcomes with a newly administered antiepileptic drug (AED) in a large population of adults with drug‐resistant focal epilepsy according...
Background and purposeStatins display anti‐inflammatory and anti‐epileptogenic properties in animal models, and may reduce the epilepsy risk in elderly humans; however, a possible modulating role on outcome in patients with status epilepticus (SE) has not been assessed.
MethodsThis cohort study was based on a prospective registry including all consecutive adults with incident SE treated in our center...
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