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Summary • Iron is indispensable for oxidation–reduction catalysis and bioenergetics but, unless appropriately handled, may generate highly toxic reactive oxygen species. • Organisms are endowed with a panoply of proteins that mediate acquisition, export, transport and storage of the transition metal, and mechanisms that maintain the intracellular labile iron pool at physiological levels. ...
The use of animals as models of neurodegenerative disorders has allowed the determination of biological targets and biomarkers of several diseases, has yielded new therapeutical perspectives, and is essential before performing novel clinical assays. This review discusses the nature, use, and limits of animal models and how to obtain them for several neurodegenerative disorders such as multiple system...
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