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Aims/hypothesis. Our aim was to test the hypothesis that TNF- protein levels in skeletal muscle are important in mediating the improvements in glucose homeostasis that are associated with diet and exercise regimens intended to reduce cardiovascular risk. Methods. We recruited 20 people with a body mass index of 32.11.2kg/m2 (mean SEM) and one other component of the metabolic syndrome. The average...
Aims/hypothesis. To study the secondary consequences of impaired suppression of endogenous glucose production (EGP) we have created a transgenic rat overexpressing the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in the kidney. The aim of this study was to determine whether peripheral insulin resistance develops in these transgenic rats. Methods. Whole body rate of glucose disappearance...
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