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Cancer is characterized by cells that disobey the stringent control mechanisms of cellular processes such as division and growth, survival, homeostasis, motility, and tissue invasion. Signalling pathways, including the mitogen-activated protein kinase (MAPK) signalling pathways, regulate these cellular processes. Not unexpectedly, cancer cells display defects in signalling pathways due to mutations...
Cancer was the first pathology to be associated with a dysfunction of gap junctions, over 40 years ago. Since then, data supporting this association have accumulated without explaining clearly the molecular events that enable connexins, the structural proteins of gap junctions, to control cell proliferation. It appears that one of the key determinants of the role of gap junctional intercellular communication...
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