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The skeletal system is a frequent site of metastatic involvement in patients with advanced malignancy, especially in those with breast and prostate cancer, lung cancer, and myeloma. Skeletal metastases involve an imbalance between the osteoclastic and osteoblastic activity of normal bone remodeling. Skeletal metastases may result in various complications, also known as skeletal-related events, including...
In the event of malignancy bone metastases are common and are inevitably accompanied with potentially serious complications that may deteriorate the clinical and performance status (PS) of patients, or even threaten life. Both radiotherapy (RT) and bisphosphonates (BPs) have an established and important role in the management of metastatic bone disease when applied as monotherapies. Their concomitant...
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