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Purpose The aims were to quantify the in vivo time-course between the oral dose, the plasma and brain exposure and the inhibitory effect on Amyloid β (Aβ) in brain and cerebrospinal fluid, and to establish the correlation between in vitro and in vivo potency of novel β-secretase (BACE1) inhibitors. Methods BACE1-mediated inhibition of Aβ was quantified in in vivo dose- and/or time-response studies...
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