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Ciprofloxacin, a broad-spectrum antimicrobial agent belonging to the fluoroquinolone family, is prescribed off-label in infants less than one year of age. Ciprofloxacin is included in the European Medicines Agency priority list of off-patent medicinal products requiring evaluation in neonates. This evaluation is undergoing within the TINN (Treat Infections in Neonates) FP7 EU project. As part of the...
Liver's development process includes growth and maturing. These changes in the structure and function have a major impact on the way drugs and other xenobiotics undergo the processes of biotransformation. Medications and their metabolic products may be toxic to the liver as well as other organs of the body. This article is a review of knowledge about the development of liver, dynamic changes in its...
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