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Organotypic cerebellar cultures derived from newborn mice were incubated for 2 weeks in vitro with antibodies that recognized the extracellular domains of the TrkB or TrkC receptor and were then examined by electron microscopy. Antibody activation of TrkB receptors resulted in development of an increased number of inhibitory Purkinje cell axosomatic synapses, while control numbers of axosomatic synapses...
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