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PurposeTo investigate a very small iron‐oxide particle (VSOP) in a mouse model of acute ischemia‐reperfusion to access the mechanism of such particles in areas of myocardial inflammation.
Materials and MethodsAnimals were injected with VSOP at several time points, in a mouse model of acute myocardial infarction (MI), before and after MI. MRI was used to localize areas of VSOP enhancement, evaluate...
Myocardial infarction (MI), and subsequent heart failure, remains a major healthcare problem in the western and developing world and leads to substantial morbidity and mortality. After MI, the ability of the myocardium to recover is closely associated with a complex immune response that often leads to adverse remodeling of the ventricle, and poor prognosis. Currently used clinical imaging modalities...
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