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Background
Cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) is one of the most studied immune checkpoint in gastric cancer (GC). However, the prognostic role of CTLA‐4 expression in GC is poorly described. This study aimed to evaluate CTLA‐4 expression in GC and its impact on survival, including patients treated with standard platinum‐based chemotherapy (CMT), and association with PD‐L1 expression...
Pancreatic cancer is related to a very weak diagnosis; the close parallel between disease incidence and mortality rates from pancreatic cancer reflects the fatal nature of this disease. Although early detection procedures are growing, they are not applicable yet for pancreatic cancer. The majority of cancer patients suffer from advanced disease, in which surgery has no potential effect. Based on the...
Chemotherapy is well recognized to induce immune responses during some chemotherapeutic drugs‐mediated tumor eradication. Here, a strategy involving blocking programmed cell death protein 1 (PD‐1) to enhance the chemotherapeutic effect of a doxorubicin nanoprodrug HA‐Psi‐DOX is proposed and the synergetic mechanism between them is further studied. The nanoprodrugs are fabricated by conjugating doxorubicin...
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