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In article number 1800901, Hung‐Wing Li, Man‐Shing Wong, and co‐workers report a smart NIR/MR dual‐modal nano‐probe for in vivo imaging of β‐amyloid in a Alzheimer's Disease transgenic mouse model. This nanoparticle‐based probe is not only non‐radiative and non‐toxic, but also highly blood brain barrier permeable and neuroprotective against Aβ induced toxicities, suggesting a great potential for early...
Senile plaques, the extracellular deposit of amyloid‐β (Aβ) peptides, are one of the neuropathological hallmarks found in Alzheimer's disease (AD) brain. The current method of brain imaging of amyloid plaques based on positron emission tomography (PET) is expensive and invasive with low spatial resolution. Thus, the development of sensitive and nonradiative amyloid‐β (Aβ)‐specific contrast agents...
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