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Delineation of how cell death mechanisms associated with Parkinson’s disease (PD) interact and whether they converge would help identify targets for neuroprotective therapies. The purpose of this study was to use a cellular model to address these issues. Catecholaminergic SH-SY5Y neuroblastoma cells were exposed to a range of compounds (dopamine, rotenone, 5,8-dihydroxy-1,4-naphtho-107 quinone [naphthazarin],...
Dopamine (50 or 100 μM) attenuated the nuclear damage and cell death due to 500 μM SIN-1, a donor of superoxide and nitric oxide, in differentiated PC12 cells whereas 200 μM dopamine did not depress cell death. Dopamine at 50–100 μM for a 4-h treatment did not show a significant cytotoxic effect on PC12 cells. Dopamine (100 μM) inhibited the decrease in mitochondrial transmembrane potential, cytochrome...
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