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The mammalian sirtuins are a family of seven NAD+‐dependent deacetylase enzymes that regulate a wide range of hepatic functions. Altered sirtuin expression in model organisms results in pleiotropic hepatic dysfunction. Furthermore, altered sirtuin expression in humans is associated with hepatic diseases including NAFLD, NASH, and HCC. In this chapter, we review the known biology of the seven sirtuins...
Finite state machine (FSM) theory has great potentialities in understanding key concepts and analyzing molecular biological systems, especially in the process of gene expression. Based on the previous research work, this paper extends the study on the control problems in metabolism and gene mutation with FSM. The goal is to interpret how to apply control technologies to process of metabolism, and...
Control-effective flux(CEF) analysis is a useful tool in assessing a metabolism. In this work, a model that utilizes existing knowledge of oxygen and redox sensing/regulatory system to assist elementary flux modes (EFMs), has been developed and CEF analysis was performed to analyze the influence of oxygen level on the transcriptional regulation in Klebsiella pneumoniae. It was found that the efficiency...
Substantial differences occur between the male and female gametophytes of Laminariajaponica Aresch in morphology and physiology. The differences were investigated by screening a cDNA library generated by suppression subtractive hybridization (SSH). Using bioinformatics and northern blot analysis, we confirmed that two genes, Ihcf6 and fcp, were preferentially expressed in male gametophytes. Analyses...
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