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The actions of opioids feature robust interindividual variability in their therapeutic and side-effects, complicating the clinical management of pain. Much of this variability is assumed to be due to genetic factors, and there is tremendous current interest in identifying the responsible genes and DNA polymorphisms. This review examines the current state of knowledge regarding opioid genetics in both...
Pain is a common complaint of patients cared for by EMS providers. The NAEMSP currently supports every EMS system having a policy to address prehospital pain management. Several studies have shown that oligoanalgesia is more the rule than the exception in prehospital care. There are physiological and non‐physiological benefits to prehospital analgesia, including improved patient comfort and improved...
In this study, we tested the hypothesis that increased body movement while steering a virtual reality game leads to the diminished experience of pain. We also investigated the relationship between presence in a virtual environment and pain intensity. 30 students of Wroclaw University participated in the within subject experiment. The participants were looking at the game through head mounted displays...
This research focuses on modeling the diffusion process that occurs in the human body when an analgesic drug is taken up, by using fractional-order impedance models (FOIMs). We discuss the measurement of a suitable feedback signal that can be used in a model-based control strategy. With this knowledge an early dawn concept of a pain sensor is presented. The major challenges that are encountered during...
In the past decades of years the systematic research on pain mechanisms has been the focus of scientists. The traditional Chinese medicine such as acupuncture has shown great potential in pain relief. Transcutaneous Electrical Acupoint Stimulation (TEAS) has been used and bicoherence of EEG has been extracted and used as evaluation criterion of pain relief in the research. In this study 12 volunteers...
The optimization of analgesic drugs delivery during general anesthesia (GA) requires to evaluate the pain/analgesia balance. Heart Rate Variability (HRV) analysis has long been shown to measure the autonomic nervous system tone, which is strongly influenced by anesthetic drugs. Power spectrum measurements are widely used to assess HRV low (LF) and high frequency (HF) ranges, related to the sympathetic...
In this paper, the pharmacodynamic effects of porous PTFE/PE/PP electret meloxicam patch on anti-inflammatory and analgesia were evaluated. The results showed that electret meloxican patch took advantage of the pharmacological effects of meloxicam and characteristics of electret that can adjust skin in biological electret state and weaken pain caused by injure and enhance the effect of analgesia and...
The aim of the present study was to investigate the possible hypnotizability-related modulation of heart activity during nociceptive stimulation (pressor pain) and during nociceptive stimulation associated with the suggestion of analgesia in not hypnotized healthy individuals with a high (Highs) and a low (Lows) hypnotic susceptibility. ECG and respirogram were recorded. Standard time and frequency...
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