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Prostate cancer constitutes a major health problem. It is estimated that the lifetime risk of western men having prostate cancer is about 30%, with the risk of dying from the cancer being 3%. Increasing age is the strongest pre-determinant for the development of prostate cancer. Virtually all cancers are adenocarcinomas, the grade being indicated by the Gleason score. Often, there are no presenting...
Prostate cancer constitutes a major health problem. It is estimated that the lifetime risk of western men having prostate cancer is about 30%, with the risk of dying from the cancer being 3%. Increasing age is the strongest pre-determinant for the development of prostate cancer. Virtually all cancers are adenocarcinomas with the grade being indicated by the Gleason score. Often, there are no presenting...
Traditionally, clinicians have used prognostic factors such as disease stage, tumour grade, nodal status and pre-treatment prostate-specific antigen (PSA) level to stratify patients for risk of disease recurrence after primary therapy. More recently, evidence from a number of studies indicates that PSA doubling time (PSADT) subsequent to biochemical failure may also be useful in predicting clinical...
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