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In various pathologic circumstances depolarized mitochondria are thought to precipitate cell death by avidly consuming cytosolic ATP. However, for as long as the inner mitochondrial membrane remains intact the reversal potentials of the adenine nucleotide translocase (ANT) and that of F 0 –F 1 ATP synthase are strategically positioned so that they oppose import of cytosolic ATP into...
It has been shown previously that human rho° cells, deprived of mitochondrial DNA and consequently of functional oxidative phosphorylation, maintain a mitochondrial membrane potential, which is necessary for their growth. The goal of our study was to determine the precise origin of this membrane potential in three rho° cell lines originating from the human HepG2, 143B, and HeLa S3 cell lines. Residual...
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