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The novel family of proteinase-activated receptors (PARs) is activated through proteolytic cleavage by serine proteinases. This family of G protein-coupled receptors and their activating enzymes are found widely throughout the body. It has been known for some time that during arthritic conditions, high levels of serine proteinases are released from joint tissue and contribute to joint degradation...
The inflammatory process is complex and the role of free radicals and antioxidants can be found in each part of it, such as the hemodynamic and permeability changes, the metabolism, and the function of the cells involved in the course of events. The main purpose of the present review is to mention the most common inflammatory processes in animals, the role of free radical formation in these, and the...
Harpagophytum procumbens (Devil’s Claw) is a traditional African herbal drug used by the natives of the Kalahari and Savannah desert regions to treat a variety of ailments. In Europe, the anti-inflammatory properties of Harpagophytum procumbens extracts (Hp) have been the basis for its popular use in the treatment of inflammatory disorders of the musculoskeletal system and of low back pain...
Osteoarthritis (OA) is a painful condition affecting over 40% of people aged over 65 years old. It has been established that it involves considerable local inflammation and, as such, is the classic example of inflammaging; a condition for which age‐related inflammation is a contributing factor. Nutrigenomics is the study of the effects of foods and food constituents on gene expression and is becoming...
Osteoarthritis (OA) is one of the most common arthritic diseases that causes of disability. For most people arthritis pain and inflammation cannot be avoided as the body ages. Although x-ray radiography is the most widely accepted method for diagnosis of joint-related diseases, but its validity of detecting OA is limited due to its inability to resolve well between soft tissues of similar densities...
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