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Environmental factors and epigenetic mechanisms are believed to contribute to Alzheimer's disease (AD). We previously documented that prenatal hypoxia aggravated the cognitive impairment and neuropathology in offspring mice. Here, we investigate the chronic hypoxia-induced epigenetic modifications in AD.The 3-month-old APPswe/PS1dE9 mice were exposed to hypoxic environment 6 hour/day for 30 days,...
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