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Ziram as a dithiocarbamate fungicide is widely used throughout the world in agriculture. We previously found that ziram significantly inhibited cytotoxic T lymphocyte activity in a dose-dependent manner. To explore the mechanism of this inhibition, we investigated ziram-induced apoptosis in human T lymphocytes. Jurkat T cells were treated with ziram at 0.031–1 μM for 2–24 h. Freshly isolated primary...
The mechanism by which endosulfan exposure causes cellular dysfunction in experimental animals and humans is not clear. In the present study, we provide experimental evidence in support of the role of oxidative stress in endosulfan toxicity. Using both cell free system and Jurkat cells as in vitro models, we demonstrate that endosulfan can generate oxygen radicals that is inhibitable by superoxide...
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