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This paper presents a novel approach based on the analysis of genetic variants from publicly available genetic profiles and the manually curated database, the National Human Genome Research Institute Catalog. Using data science techniques, genetic variants are identified in the collected participant profiles and then indexed as risk variants in the National Human Genome Research Institute Catalog...
Each human body hosts, on the surface and inside its body, trillions of microorganisms, which are essential in the functioning of the human organisms. The importance of these communities of microorganisms in our lives is major since researchers all over the world consider them a "second human genome". Understanding how these organisms interact with their human hosts could explain different...
The socioeconomic transformations in the last decades and its consequent changes to societies lifestyle have increased the incidence of chronic diseases. Genomic medicine has suggested that the exposure to risk factors since conception may influence gene expression and consequently induce the development of chronic diseases in adulthood . Scientific papers bringing up these discoveries indicate that...
Most common complex traits such as obesity, hypertension, diabetes, and cancers are known to be associated with multiple genes, environmental factors, and epistasis. Recently, the development of advanced genotyping technologies allows us to perform the genome-wide association studies (GWAS). For detecting the effects of multiple genes on complex traits, many approaches have been proposed for GWAS...
The human body plays host to thousands of bacterial species in a variety of ecosystems. Until recently, microbial communities have been impossible to investigate thoroughly, as the vast majority of bacteria cannot be cultured through laboratory techniques. New technologies (e.g. high-throughput sequencing, 16S rRNA surveys) allow us to deeply sample the genetic content of a microbial environment in...
Genome-wide association studies (GWAS) provide a new and powerful approach to investigate the effect of inherited genetic variation on risks of complex diseases. With recent advances in genotyping technology, genome-wide association studies are now becoming a reality. Within the past two years, scientists have successfully replicated genetic risks of several complex diseases including cancers, obesity,...
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