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The apolipoprotein E (apoE) ε4 allele is the primary genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE in the brain is produced primarily by astrocytes; once secreted from these cells, apoE binds lipids and forms high‐density lipoprotein (HDL)‐like particles. Accumulation of amyloid‐β protein (Aβ) in the brain is a key hallmark of AD, and is thought to initiate a pathogenic cascade...
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