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Die Therapie des Adenokarzinoms des Pankreas stellt ein ungelöstes Problem der modernen Medizin dar. Die molekulare Genese des Pankreaskarzinoms ist durch Mutationen in Onkogenen und Tumorsuppressorgenen sowie epigenetischen Veränderungen gekennzeichnet. Es resultiert eine Apoptoseresistenz, die zur Therapieresistenz konventioneller Zytostatika führt. Interessante therapeutische Ansatzpunkte stellen...
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