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Primary liver cancer (PLC) is the third most deadly and fifth most common cancer in the world (Parkin et al. 1999), with an estimated 626,000 or 5.7% of new cancer cases and almost as many deaths in 2002 (Parkin et al. 2005). Liver cancer is an ancient disease and its description can be found in Huangdi Neijing, an ancient Chinese medical textbook also known as Yellow Emperor’s Inner Canon dated back...
Hepatocellular carcinoma (HCC) patients with >3 cm and/or multiple lesions can only expect a prolonged survival if they are eligible for a surgical treatment, e.g., resection or liver transplantation. Liver transplantation is the best option as it cures both the HCC and the underlying disease and is therefore associated with a better disease-free survival than resection. Yet, liver transplantation...
We present a computational framework to analyze MALDI-TOF mass spectrometry data for quantitative comparison of peptides and glycans in serum. In particular, we introduce an algorithm that detects peaks that are differentially abundant in a subgroup of patients. The method is applied to identify candidate biomarkers in serum samples of 203 participants from Egypt; 73 hepatocellular carcinoma (HCC)...
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