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In this work, the feasibility of classifying amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer's disease, was investigated using fMRI activation patterns in the medial temporal lobes (MTL). The activation volume or relative activation extent in each of fourteen subregions of the MTL, when subjects were performing memory tasks, served as features for radial basis function networks...
Alzheimer's disease (AD) is the most common neurodegenerative disease in individuals older than 65 years of age. Nowadays, the imaging study of AD mostly focuses on morphologic measurement of the early predilection sites such as hippocampus. However, there is still lack of a specific parameter for early diagnosis. In this study, texture analysis was performed on MR images of three groups including...
The study the age-related changes of hippocampus is an important issue in neuroscience. Here, we established the methodology of analyzing 18F-FDG brain PET images based on functional connectivity, and studied the age-related changes of functional networks in hippocampus detected by this method. 195 healthy volunteers were divided into 4 groups by age and were scanned in a resting state. The functional...
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