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In this paper, we investigated effects of deep brain stimulation (DBS) on Parkinson's disease (PD) when different target sites in the basal ganglia are stimulated. The targets which are investigated are subthalamic nucleus (STN), globus pallidus interna (GPi), and globus pallidus externa (GPe). For this purpose we used a computational model of the basal ganglia-thalamocortical system (BGTCS) with...
Saccades are rapid, frequent eye movements that shift the fovea onto objects of interest. Several areas of the brain, including the frontal cortical areas, Lateral Intraparietal (LIP) cortex, Basal Ganglia (BG), Superior Colliculus (SC) and the brainstem reticular formation are believed to be involved in saccade generation. Models of saccade generation, however, tend to focus heavily on the determination...
In this paper, we present a model for the generation of ideas within a creative thinking/brainstorming context. In the model, ideas emerge as conceptual combinations from the interaction of complex dynamics at several semantic levels: features, concepts, categories, and previously generated ideas. This dynamics is shaped by external information on task context, constraints and goals, and is modulated...
Parkinson's Disease (PD) is associated with a reduced level of dopamine in the substantia nigra pars compacta (SNc) which is one of five nuclei in the basal ganglia, a part of the brain that plays a key role in voluntary movement. There are three pathways for information transmission through the basal ganglia: the ‘Direct’ pathway, going straight to the Globus Pallidus internal (GPi) from the Striatum,...
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