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Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization with potentially improved in vivo stability, drug payload, and minimal interference outside of the focal zone compared with microbubbles. While the feasibility of blood-brain barrier (BBB) opening using nanodroplets has been previously reported, characterization of the associated delivery has not been...
In order to understand the effect of microbubble driven by ultrasound to the skin, we tried to investigate the effect of bubble behaviors to the skin-life soft material, bovine gelatine MDCK cells cultured. Using high-speed video camera and fluorescene microscope, the bubble behaviors and the effect to the cells were investigated. Based on observations using high-speed video camera, it was found that...
Nanoscale perfluorocarbon droplets that are in the liquid phase at physiological temperatures, but which can be converted to gas using ultrasound, offer potential as a contrast agent for the detection and therapy of solid tumours. Nanoparticles such as quantum dots can also be encapsulated within PFC droplets, enabling multi-modal imaging and controlled nanoparticle release. In this work, experiments...
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