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A supermagnetic iron oxide (SPIO) microspheres is emerging as an ideal tool for cell tracking and drug targeting delivery. However, its low intracellular labeling efficiency has limited the potential usage. We have developed CdTe-incorporated CMCH/SiO2-coated core-shell composite microspheres, Fe3O4@SiO2@CMCH/CdTe (FSCC), with diameters of 210 nm, as a multifunctional magnetic vector that can efficiently...
Cardiovascular implants including bypass grafts, heart valves and stents are prone to calcification, thrombogenicity and structural failure. To overcome these problems we have developed and patented a family of nanocomposite polymers based on polyhedral oligomeric silsesquioxane (POSS) nanoparticles and poly(carbonate urea)urethane (PCU). In addition, we have been working on bonding bioactive molecules...
This paper describes the synthesis of Fe3O4/Poly[3-(trimethylamlno)ethyl methacrylate iodine] (PTMAI) /CdTe bifunctional nano gene vector for targeting DNA delivery. In this approach, Poly[2-(dimethylamlno)ethyl methacrylate] (PDMA) was grafted on the Fe3O4 nanoparticles by surface-initiated transfer radical polymerization (ATRP). The ternary amine groups of PDMA can be alkylated by the iodomethane...
Hydroxyapatite (hydroxyfluorapatite) - collagen and composite materials are synthesized using directed diffusion of ions from solutions on collagen fibers. Computer tomography indicates that the salt component is rather uniformly distributed over the organic matrix. According to the electron microscopic data,the composite materials involve salt nanocrystals (less than 1m in size), which are uniformly...
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