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Nous avons montre l'existence d'un rythme circadien de la reponse a la chimiotherapie par docetaxel chez la souris C3H/HeN porteuse de l'adenocarcinome mammaire MA13/C. Nous etudions sa relation avec l'expression de la proteine anti-apoptotique BCL-2 dans la moelle osseuse et dans le tissu tumoral. Il existe une regulation circadienne de l'expression de BCL-2 dans la moelle osseuse, peu modifiee par...
NO presente des activites pro- et anti-apoptotiques. Les parametres gouvernant ces effets commencent a etre elucides. Parmi les facteurs orientant l'action de NO figurent le type et l'etat redox des cellules, la concentration et le flux de NO, la possibilite de reagir avec le superoxyde genere au niveau des mitochondries. Les cibles de NO incluent des molecules impliquees dans la reparation des dommages...
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