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We developed a fast dispersive-type near-infrared in vivo Raman spectroscopy system for improving early detection of lung cancers. We have measured spectra from 50 patients. Combined principal component analysis and linear discriminate analysis of the acquired data demonstrated that malignant and benign lesions can be differentiated with around 90% accuracy.
Urinary tract infection diagnosis and antibiogram require a 48 hour waiting period using conventional methods. This results in ineffective treatments, increased costs and most importantly in increased resistance to antibiotics. In this work, a novel method for classifying bacteria and determining their sensitivity to an antibiotic using Raman spectroscopy is described. Raman spectra of three species...
In this paper, we studied skin roughness, so called skin Xerosis, with Raman Spectroscopy technique. The main goal of this study was to determine the features from the Raman spectral data associated with skin xerosis and finally detecting Xerosis from normal skin by using an optimal classification method. The Raman spectral dataset was constructed from two classes of spectral data, 70 spectra of normal...
66 samples from the human oral mucosa tissue, including 43 normal and 23 malignant tissue samples were measured by confocal Raman microspectroscopy. The low signal-to-background ratio spectra from human oral mucosa tissues were obtained by this technique without any sample preparation. A preprocessed algorithm based on wavelet analysis was used to reduce noise and eliminate background of Raman spectra...
A rapid trapping and detection method for clinical isolates Helicobacterpylori (H.pylori) analysis is reported in this study. Different strain of H.pylori are trapped in 3 dimension dielectrophoresis chip (DEP) under the condition of 20 mM PBS, voltage at 20 Vp-p and frequency at 300 kHz. Hpylori #238(Wild type) presents more detail peaks in Raman spectra than that of H. pylori #603(gene knockout)...
The purpose of this study is to explore the feasibility of combining near-infrared (NIR) autofluorescence and Raman spectroscopy to enhance the in vivo detection of cervical intraepithelial neoplasia.
Frequent measurement of blood glucose is crucial for diabetic patients in managing the glucose level and thus reducing the severe complications associated with the disease. Raman spectroscopy is one of the non-invasive optical techniques that have been proposed for physiological glucose measurement. In this study, we used a relatively inexpensive, compact and portable Raman system which can be made...
In this article, fuzzy logic approach is proposed for sample differentiation using Raman spectroscopy in order to characterize various biomedical samples for decision-making and medical diagnosis. Raman spectra are relatively weak signals whose features are inevitably affected by various types of noises during its calibration process. These noises must be eliminated to an acceptable level. Fuzzy logic...
Laser-induced fluorescence and Raman spectroscopy of serum for detect colon cancer was investigated in this paper. The difference to serum spectrum was discovered. Three Raman peaks were consistently observed from normal blood serum emission using 488.0 nm and 514.5 nm excitation of an Ar-ion laser. While no Raman peak or slight Raman peaks were detected from colon cancer's cases. In addition, the...
Laser-induced fluorescence (LIF) and Raman spectra were measured from normal and tumorous human serum in an attempt to discover some values useful in discrimination between normal and tumorous cases. Red shift of fluorescence peak and decrease of fluorescence intensity were observed after samples radiated by laser. According to one thousand twenty-two samples' spectra, three parameters alpha, beta...
Laser-induced fluorescence spectroscopy (LIF) and Raman spectrum of serum for diagnosis of rectum cancer were investigated by criteria of three parametric modes in this paper. The aim of this study was in an attempt to find the difference normal and rectum cancer cases, therefore 89 rectum cancer samples were measured using fluorescence and Raman spectrum. The experimental result showed that there...
We present a three parametric model using Raman and fluorescence spectroscopy for detection and analysis of esophagus dysphasia and esophagus cancer. The model was set up from more than 200 samples. And 40 samples were used to test this algorithm of the model prospectively. The serum spectra were excited by laser of the wavelength 488.0 nm and 514.5 nm. The apparent differences of auto-fluorescence...
Summary form only given. Recent technological advances have enabled the application of optical diagnostic techniques to human tissue and has suggested application of optical spectroscopy to a variety of biomedical problems. This work is a preliminary investigation of detection and monitoring of polydimethylsiloxane (PDMS) leakage in human breast tissue using Raman spectroscopy. The objectives of this...
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