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This report showed some physico-chemical properties and structural features about UL41 protein predicted by some software and on-line tools. The analysis showed both the signal peptide and the trans membrance region are not found. Meanwhile, the protein has twenty-four potential phosphorylation sites. In addition, the protein has more hydrophilic amine acid districts than hydrophobic districts and...
The Duck Plague Virus (DPV) is the causative agent of Duck plague, which causes significant economic losses in the commercial duck industry all over the world. Our laboratory had identified and sequenced the DPV UL41 gene. Bioinformatics analysis of DPV UL41 gene were performed by some software and online tools. The results showed that GC content of duck plague virus UL41 gene was 42.42%, which encoded...
Ribonucleases (RNases) constitute a cellular function of exo- and endo-nucleases in all living organisms include vertebrate, bacteria, mold and plant. Human ribonuclease A (hRNaseA) super family consists of thirteen members with high structure similarities. Among which hRNase3 has multiple functions such as RNase, cytotoxicity, and heap ran sulfate (HS) binding activity. Employing Clustal W2 multiple...
Human ribonuclease A (hRNaseA) super family members have similar biological functions such as catalytic activities against specific RNA substrates. However, these enzymes with high sequence similarity may exhibit divergent physiological functions other than RNase activity, for example, angio genesis and innate immunity. In our investigation, a novel heparin-binding motif (HBM), RWRCK, identified from...
Based on the selected chemical and physical properties of amino acids, a dynamic 3-D graphical representation of protein sequences is outlined. We introduce the numerical characterization of protein graphs as descriptors to analyze and compare the nine ND5 proteins, and the results consist with the known fact of evolution. The graph of protein sequences have good visibility, the approach is simple,...
The pituitary gonadotropin luteinizing hormone (LH) play important roles in regulating gonad function and are essential for normal reproductive function in mammals. In this paper, compared with homologous sequences from available mammals, they displayed a high degree of conservation. Our results provided an insight into the characteristics of LHß.
High-risk types of human papillomaviruses (HPVs) cause cervical cancer, and the second most common tumor in women worldwide, and the HPV E6 protein is one of two viral oncoproteins that is expressed in virtually all HPV-positive cancers. Therefore, how can we identify whether it is a risk type of HPVs by means of E6 properties is very useful and necessary to the diagnosis and the remedy of cervical...
This research is to define and develop the Pandemic Influenza simulation program. There are 3 parameters to determine whether a virus is potentially dangerous or not: (1) infectivity (2) virulence and (3) contagiousness. Avian Influenza has characteristics as follows: relatively high infectivity, high virulence and low contagiousness. On the other hand, Swine Influenza has characteristics as follows:...
Maps of protein-protein interactions (PPIs) are essential to uncover cellular processes and metabolic processes in a cell. However, various high-throughput biological experiments are time-consuming and labor-intensive, resulting in interactions of high false positive and false negative rates. The fact that most interaction networks remain sparse and incomplete motivates scientists to develop computational...
MicroRNAs are small regulatory RNAs that play an important role in diverse biological processes, by post-transcriptionally regulating the expression of messenger RNAs. Recent advances in genome synthesis technology allow for manipulation of existing genes and the creation of novel genomic sequences to specification, with a tremendous number of applications. Incorporation of miRNA sites in synthetic...
Summary form only given. Arsenic is shown to participate in many of transduction pathways in cancer cells. However, up to now, the mechanism of protein-arsenic interactions is still remaining unknown. This study aims at investigating whether the sequence composition of arsenic-binding proteins is distinct to that of background distribution. We first collected two sets of potential arsenic-binding...
The attachment of a glycosylphosphatidylinositol (GPI) is one of the most important posttranslational protein modifications and plays an important role in many vital reactions. It is well known that most GPI-anchored proteins (GPI-APs), such as receptors, nucleotidases, proteinases, immune antigens, and prion protein, are associated with serious human diseases. Consequently, the annotation of novel...
In this paper we propose a new algorithm to predict the phosphorylation site specificities of 478 human protein kinases based on the primary structures of the catalytic domains of these enzymes. Existing methods deduce the specificity of a protein kinase through the alignment of the amino acid sequences of phospho-sites targeted by the kinase to generate a consensus sequence or they use machine learning...
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