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As a response to a letter to the editor sent to Lung Cancer Journal we have tried to add further insight in the prognostic role of K-ras mutations found in serum in non-small cell lung cancer patients.
A hypothesis of multistep carcinogenesis of lung adenocarcinoma from atypical adenomatous hyperplasia (AAH) to invasive adenocarcinoma through bronchioloalveolar carcinoma (BAC) has been proposed. However, the genetic alterations that play a role during these processes are not yet clear. Recently, somatic mutations of the epidermal growth factor receptor (EGFR) gene were found in lung adenocarcinoma...
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