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Spatial-resolved light delivery in the living mammalian brain is of utmost importance in optogenetics experiments, since it allows for combining cell-type specificity with spatial selective optical control of neural activity. This can be achieved at sub-cellular resolution in first cortical layers with two-photon microscopy, while sub-cortical regions can be accessed by using waveguide-based devices...
Light-induced stimulation and inhibition of neuronal activity has been recently made possible by optogenetics. In optogenetics, specific light-sensitive proteins, called opsins, are genetically targeted into specific neuronal cell types in an animal model. When light of the appropriate wavelength is delivered into the brain, the light-activated proteins respond by stimulating or inhibiting the firing...
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