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Mammalian development commences with the totipotent zygote which is capable of developing into all the specialized cells that make up the adult animal. As development unfolds, cells of the early embryo proliferate and differentiate into the first two lineages, the pluripotent inner cell mass and the trophectoderm. Pluripotent cells can be isolated, adapted and propagated indefinitely in vitro in an...
Cellular states are plastic, and even terminally differentiated cells can be reprogrammed to pluripotency by ectopic expression of selected transcription factors, yet it remains inefficient in practice. Cell reprogramming is remarkable for its potential to impact research and therapies because induced pluripotent stem (iPS) cells are similar to embryo stem (ES) cells in many aspects so that they are...
Human embryonic stem cells are pluripotent cells derived from early human embryo and retain a potential to differentiate into all adult cell types. They provide vast opportunities in cell replacement therapies and are expected to become significant tools in drug discovery as well as in the studies of cellular and developmental functions of human genes. The progress in applying different types of DNA...
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