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In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields...
BACKGROUNDDepression is common during and after breast cancer treatment. However, the role of specific therapeutic modalities and related biologic mechanisms remains unclear. Radiation is an essential component of breast‐conserving therapy and may contribute to depression in patients with breast cancer through the activation of inflammatory pathways.
METHODSDepressive symptoms and inflammatory mediators,...
Objective Ionizing radiation, an established breast cancer risk factor, has been shown to induce oxidative damage and chronic inflammation. Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk. Methods We estimated breast cancer risk for 28 common variants in 16 candidate genes involved in these pathways among 859 breast...
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