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Caspase-8 (CASP8) plays a critical role in regulating apoptosis, and its functional polymorphisms may modify cancer risk. We investigated the possible association between CASP8 −652 6N ins/del (rs3834129) and the risk of breast cancer in a sample of Iranian population. This case–control study was done on 236 breast cancer patients and 203 cancer free healthy female. We designed a rapid and simple...
Caspase-8 (CASP8) is an initiator caspase implicated in the process of apoptosis in breast cancer cells. Attention has been drawn upon two polymorphisms: CASP8 D302H (rs1045485) and, more recently, CASP8 −652 6N del (rs3834129). The CASP8 −652 6N del polymorphism remains an open field, as studies are controversial. This meta-analysis aims to examine: (i) the association between CASP8 −652 6N del and...
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